Two sample MR report
HLA-DQB1_T Proliferating against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | 0.4478312 | 0.1267755 | 0.0046944 |
| Weighted median | 13 | -0.1328281 | 0.0247448 | 0.0000001 |
| Inverse variance weighted | 13 | -0.1253137 | 0.0317172 | 0.0000778 |
| Simple mode | 13 | -0.1358336 | 0.0315376 | 0.0010192 |
| Weighted mode | 13 | -0.1339718 | 0.0309550 | 0.0009822 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.14853 | 11 | 0.1357058 |
| Inverse variance weighted | 46.87666 | 12 | 0.0000049 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.23715 | 0.0518353 | 0.0007967 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004552 | 3e-07 | TRUE | 0.0474971 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
